Central leptin signaling transmits positive valence

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Alhadeff AL, Conway SM, Ong ZY, Wald HS, Roitman MF, Grill HJ (2019) Brain Research

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Phasic dopamine responses to a food-predictive cue are suppressed by the glucagon-like peptide-1 receptor agonist Exendin-4
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Females are less sensitive than males to the motivational-and dopamine-suppressing effects of kappa opioid receptor activation