Relative timing between kappa opioid receptor activation and cocaine determines the impact on reward and dopamine release

Chartoff EH, Ebner SR, Sparrow A, Potter D, Baker PM, Ragozzino ME, Roitman MF (2016) Neuropsychopharmacology

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A descending dopamine pathway conserved from basal vertebrates to mammals

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Physiological state gates acquisition and expression of mesolimbic reward prediction signals